adrenal Anxiety B12 Depression hormones MTHFR sleep stress

The Nutritional Connection to Sleep Biology

The quality of our sleep is deeply rooted in our biology. The nutrients we eat, the way we regulate blood sugar and how our hormones and neurotransmitters communicate, all contribute to sleep quality. When these systems are out of sync we can find ourselves lying awake for hours or waking at 3 am. Supporting your body’s hormones and neurotransmitters can help restore natural and restorative sleep patterns.

Poor sleep can affect your mood, increase anxiety and lower your ability to cope with stress. In clinic, I often see disrupted sleep contributing significantly to both mental and physical issues. Just one week of shortened sleep can raise inflammation, blunt insulin sensitivity and disturb cortisol balance. Without deep, restorative sleep, the body misses its nightly reset. Cortisol stays high, your body clock drifts, and motivation, focus and emotional balance start to suffer.


Sleep should feel effortless, yet many people find themselves restless or wide awake at 3 a.m. In functional nutrition, sleep patterns mirror what’s happening with hormones and neurotransmitters. During deep sleep, the brain clears waste through the glymphatic system, this is its built-in detox network. Plaque-forming compounds are flushed away, mood and memory are consolidated, and the nervous system resets. Supporting this process helps both body and mind recover naturally.

Why You Might Struggle to Fall Asleep

Falling asleep depends on converting serotonin into melatonin. This process relies on:

  • Tryptophan-rich foods, like eggs, chicken, turkey and seeds
  • Key nutrients like vitamin B6, folate, zinc and magnesium
  • Darkness, as light exposure at night suppresses melatonin release
  • Stable blood sugar, because late-evening dips can raise cortisol and keep you wired

Low serotonin is often linked to poor nutrient status, gut inflammation or low protein intake. This not only affects mood but also limits melatonin production, making it harder to drift off to sleep.

If falling asleep is a struggle, support serotonin production through balanced, nutrient-dense meals, regular protein and additional magnesium and B6. An organic acid test can measure metabolites of serotonin to help you understand the cause of your sleep issues.


Why You Might Wake in the Middle of the Night
Blood Sugar Dips

When glucose drops overnight, adrenaline rises to correct it. This process will usually wake you up. A small protein-based bedtime snack can help with this, but good blood sugar balance starts much earlier in the day. Keeping daytime meals regular and protein-rich also reduces overnight blood sugar crashes.

Overactive Stress Response

Chronic stress can keep cortisol high at night, leading to early-morning waking. Calming nutrients and adaptogens like glycine, L-theanine and hydrolysed milk peptides can support adrenal rhythm and help retrain your sleep–wake cycle.

Hormonal Issues

Hot flushes or night sweats commonly disturb sleep, especially when blood sugar or stress hormones are unsteady. Supporting healthy oestrogen metabolism through methylation and liver support can reduce these episodes. You can investigate both stress and sex hormones using the DUTCH Complete functional lab test. If you’re using hormone therapy, review the balance with your GP.


Night-time Toilet Trips

Frequent urination can result from bladder irritation, blood sugar imbalance or mild dehydration. In men, an enlarged prostate can also contribute. Gentle hydration through the day and maintaining consistent mineral intake can be supportive. Food intolerances can also contribute to bladder irritation.

Natural Sleep Support

If you’ve already worked on bedtime habits but still struggle with sleep, then natural sleep support can make a difference. Magnesium remains a trusted choice for relaxation and nervous system balance, but beyond this, other gentle options include:

  • Botanicals such as Montmorency cherry, lavender or chamomile for increasing calming neurotransmitters
  • Nutrients that calm the nervous system like glycine, B6, B12 and omega 3
  • Amino acids like tryptophan or 5-HTP to aid serotonin and melatonin production (avoid if using SSRIs) or L-theanine to increase GABA levels
  • Niacin (vitamin B3) to help convert tryptophan into sleep-supportive neurotransmitters
Reset Your Body Clock
  • Light exposure powerfully regulates the circadian rhythm. Aim for at least 10 minutes of natural daylight soon after waking to boost daytime alertness. In the evening, dim the lights and limit screens to allow melatonin to rise naturally.
When to Investigate Further

If you still wake unrefreshed or experience persistent insomnia, it may be worth checking your cortisol rhythm, hormones, or blood sugar regulation. Discuss fasting glucose or HbA1c testing with your GP, or explore functional testing to uncover deeper patterns.

If sleep has become a nightly battle, take a closer look at your biological sleep cues to help understand what’s really going on. Working with a practitioner helps you identify these underlying patterns and rebuild the foundation for deep, restorative rest.

If you would like support with sleep or other health concerns, get in touch.


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    Sarah

    I’m Sarah Hanratty, a Clinical Nutritionist with a BSc in Nutritional Medicine, an MSc in Public Health Nutrition and years of clinical experience. I help people uncover the root causes behind symptoms like fatigue, anxiety, digestive issues and low mood. My work focuses on the powerful link between gut health and mental wellbeing, using science-led nutrition to restore balance from the inside out.

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